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https://hdl.handle.net/2440/73335
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Type: | Journal article |
Title: | New cylindrical peptide assemblies defined by extended parallel β-sheets |
Other Titles: | New cylindrical peptide assemblies defined by extended parallel beta-sheets |
Author: | Pehere, A. Sumby, C. Abell, A. |
Citation: | Organic and Biomolecular Chemistry, 2013; 11(3):425-429 |
Publisher: | Royal Soc Chemistry |
Issue Date: | 2013 |
ISSN: | 1477-0520 1477-0539 |
Statement of Responsibility: | Ashok D. Pehere, Christopher J. Sumby and Andrew D. Abell |
Abstract: | A new approach to non-covalent peptide-based nanotubular or rod-like structures is presented, whereby the monomeric units are preorganised into a β-strand geometry that templates the formation of an extended and unusual parallel β-sheet rod-like structure. The conformational constraint is introduced by Huisgen cycloaddition to give a triazole-based macrocycle, with the resulting self-assembled structures stabilized by a well-defined series of intermolecular hydrogen bonds. |
Keywords: | Oligopeptides Protein Structure, Secondary Models, Molecular |
Description: | Received 17 Aug 2012, Accepted 25 Sep 2012, First published on the web 26 Sep 2012 (from RCS website) |
Rights: | © The Royal Society of Chemistry |
DOI: | 10.1039/C2OB26637G |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1039/c2ob26637g |
Appears in Collections: | Aurora harvest Chemistry publications Environment Institute publications IPAS publications |
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