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Type: Journal article
Title: Targeting classical but not neurogenic inflammation reduces peritumoral oedema in secondary brain tumours
Author: Lewis, K.
Harford-Wright, E.
Vink, R.
Ghabriel, M.
Citation: Journal of Neuroimmunology, 2012; 250(1-2):59-65
Publisher: Elsevier Science BV
Issue Date: 2012
ISSN: 0165-5728
Statement of
Kate M. Lewis, Elizabeth Harford-Wright, Robert Vink and Mounir N. Ghabriel
Abstract: Dexamethasone, the standard treatment for peritumoral brain oedema, inhibits classical inflammation. Neurogenic inflammation, which acts via substance P (SP), has been implicated in vasogenic oedema in animal models of CNS injury. SP is elevated within and outside CNS tumours. This study investigated the efficacy of NK1 receptor antagonists, which block SP, compared with dexamethasone treatment, in a rat model of tumorigenesis. Dexamethasone reverted normal brain water content and reduced Evans blue and albumin extravasation, while NK1 antagonists did not ameliorate oedema formation. We conclude that classical inflammation rather than neurogenic inflammation drives peritumoral oedema in this brain tumour model.
Keywords: Blood-Brain Barrier; Animals; Rats; Rats, Wistar; Brain Neoplasms; Brain Edema; Disease Models, Animal; Inflammation; Dexamethasone; Substance P; Receptors, Neurokinin-1; Anti-Inflammatory Agents; Male
Rights: © 2012 Elsevier B.V. All rights reserved.
RMID: 0020121471
DOI: 10.1016/j.jneuroim.2012.06.001
Appears in Collections:Medical Sciences publications

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