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https://hdl.handle.net/2440/7374
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Type: | Journal article |
Title: | LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes |
Author: | Meyaard, L. Adema, G. Chang, C. Woollatt, E. Sutherland, G. Lanier, L. Phillips, J. |
Citation: | Immunity, 1997; 7(2):283-290 |
Publisher: | CELL PRESS |
Issue Date: | 1997 |
ISSN: | 1074-7613 1097-4180 |
Statement of Responsibility: | Linde Meyaard, Gosse J Adema, Chiwen Chang, Erica Woollatt, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips |
Abstract: | In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation. |
Keywords: | Leukocytes, Mononuclear Killer Cells, Natural HL-60 Cells Jurkat Cells Tumor Cells, Cultured Humans Intracellular Signaling Peptides and Proteins Receptors, Immunologic DNA, Complementary RNA, Messenger Cloning, Molecular Amino Acid Sequence Base Sequence Protein Binding Molecular Sequence Data Protein Tyrosine Phosphatases Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatase, Non-Receptor Type 11 |
DOI: | 10.1016/S1074-7613(00)80530-0 |
Published version: | http://dx.doi.org/10.1016/s1074-7613(00)80530-0 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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