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https://hdl.handle.net/2440/7375
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dc.contributor.author | Shibuya, A. | - |
dc.contributor.author | Campbell, D. | - |
dc.contributor.author | Hannum, C. | - |
dc.contributor.author | Yssel, H. | - |
dc.contributor.author | Franz-Bacon, K. | - |
dc.contributor.author | McClanahan, T. | - |
dc.contributor.author | Kitamura, T. | - |
dc.contributor.author | Nicholl, J. | - |
dc.contributor.author | Sutherland, G. | - |
dc.contributor.author | Lanier, L. | - |
dc.contributor.author | Phillips, J. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Immunity, 1996; 4(6):573-581 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.issn | 1097-4180 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7375 | - |
dc.description.abstract | Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloantigen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. | - |
dc.description.statementofresponsibility | Akira Shibuya, David Campbell, Charles Hannum, Hans Yssel, Karin Franz-Bacon, Terrill McClanahan, Toshio Kitamura, Jillian Nicholl, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.source.uri | http://dx.doi.org/10.1016/s1074-7613(00)70060-4 | - |
dc.subject | B-Lymphocytes | - |
dc.subject | Killer Cells, Natural | - |
dc.subject | T-Lymphocytes, Cytotoxic | - |
dc.subject | Monocytes | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Cell Adhesion Molecules | - |
dc.subject | Membrane Proteins | - |
dc.subject | DNA, Complementary | - |
dc.subject | Antigens, Differentiation, T-Lymphocyte | - |
dc.subject | Antigens, Surface | - |
dc.subject | Epitopes | - |
dc.subject | Lymphokines | - |
dc.subject | Cloning, Molecular | - |
dc.subject | Signal Transduction | - |
dc.subject | Cytotoxicity, Immunologic | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Base Sequence | - |
dc.subject | Molecular Sequence Data | - |
dc.title | DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S1074-7613(00)70060-4 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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