Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7377
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dc.contributor.author | Sandrin, M. | - |
dc.contributor.author | Henning, M. | - |
dc.contributor.author | Lo, M. | - |
dc.contributor.author | Baker, E. | - |
dc.contributor.author | Sutherland, G. | - |
dc.contributor.author | McKenzie, I. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Immunogenetics, 1996; 43(1-2):13-19 | - |
dc.identifier.issn | 0093-7711 | - |
dc.identifier.issn | 1432-1211 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7377 | - |
dc.description.abstract | Ly9 is a mouse cell membrane antigen found on all lymphocytes and coded for by a gene that maps to chromosome 1. We previously described the isolation and characterization of a full-length cDNA clone for mouse Ly9. Using cross-species hybridization we isolated cDNA clones encoding the human homologue Humly9. Analysis of the predicted protein sequence suggests that the extra-cellular portion of the Humly9 molecules is composed of four Ig-like domains: a V domain (V) without disulphide bonds and a truncated C2 domain (tC2) with two disulphide bonds, a second V domain without disulphide bonds and a second tC2 with two disulphide bonds, i.e., as V-tC2-V-tC2. The gene encoding Humly9 was mapped to chromosome 1 by analysis of human/hamster hybrids, and more specifically to the 1q22 region by in situ hybridization. The protein sequence data support the view that Humly9 belongs to the immunoglobulin-superfamily subgroup which includes CD48, CD2, and LFA-3. | - |
dc.description.statementofresponsibility | Mauro S. Sandrin, Margaret M. Henning, Michael F. Lo, Elizabeth Baker, Grant R. Sutherland, Ian F. C. McKenzie | - |
dc.language.iso | en | - |
dc.publisher | Springer-Verlag | - |
dc.rights | © Springer-Verlag 1995 | - |
dc.source.uri | http://dx.doi.org/10.1007/bf00186599 | - |
dc.subject | Hybrid Cells | - |
dc.title | Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/BF00186599 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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