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https://hdl.handle.net/2440/73913
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Type: | Journal article |
Title: | Effect of dialysis modality on survival of hepatitis C-infected ESRF patients |
Author: | Bose, B. McDonald, S. Hawley, C. Brown, F. Badve, S. Wiggins, K. Bannister, K. Boudville, N. Clayton, P. Johnson, D. |
Citation: | Clinical Journal of the American Society of Nephrology, 2011; 6(11):2657-2661 |
Publisher: | American Society of Nephrology |
Issue Date: | 2011 |
ISSN: | 1555-9041 1555-905X |
Statement of Responsibility: | Bhadran Bose, Stephen P. McDonald, Carmel M. Hawley, Fiona G. Brown, Sunil V. Badve, Kathryn J. Wiggins, Kym M. Bannister, Neil Boudville, Philip Clayton, David W. Johnson |
Abstract: | <h4>Background and objectives</h4>Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in end-stage renal failure (ESRF) patients. Despite a lower incidence and risk of transmission of HCV infection with peritoneal dialysis (PD), the optimal dialysis modality for HCV-infected ESRF patients is not known. The aim of this study was to evaluate the impact of dialysis modality on the survival of HCV-infected ESRF patients.<h4>Design, setting, participants, & measurements</h4>The study included all adult incident ESRF patients in Australia and New Zealand who commenced dialysis between January 1, 1994, and December 31, 2008, and were HCV antibody-positive at the time of dialysis commencement. Time to all-cause mortality was compared between hemodialysis (HD) and PD according to modality assignment at day 90, using Cox proportional hazards model analysis.<h4>Results</h4>A total of 424 HCV-infected ESRF patients commenced dialysis during the study period and survived for at least 90 days (PD n = 134; HD n = 290). Mortality rates were comparable between PD and HD in the first year (10.7 versus 13.8 deaths per 100 patient-years, respectively; adjusted hazard ratio [HR] 0.65, 95% CI 0.34 to 1.26) and thereafter (20 versus 15.9 deaths per 100 patient-years, respectively; HR 1.27, 95% CI 0.86 to 1.88).<h4>Conclusions</h4>The survival of HCV-infected ESRF patients is comparable between PD and HD. |
Keywords: | Humans Hepatitis C Kidney Failure, Chronic Hepatitis C Antibodies Treatment Outcome Renal Dialysis Peritoneal Dialysis Registries Survival Rate Proportional Hazards Models Risk Assessment Risk Factors Chi-Square Distribution Survival Analysis Retrospective Studies Time Factors Adult Aged Middle Aged Australia New Zealand Biomarkers |
Rights: | Copyright © 2011 by the American Society of Nephrology |
DOI: | 10.2215/CJN.02200311 |
Published version: | http://dx.doi.org/10.2215/cjn.02200311 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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