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https://hdl.handle.net/2440/73934
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Type: | Journal article |
Title: | Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance |
Author: | Bowie, J. Separovic, F. Tyler, M. |
Citation: | Peptides, 2012; 37(1):174-188 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2012 |
ISSN: | 0196-9781 1873-5169 |
Statement of Responsibility: | John H. Bowie, Frances Separovic, Michael J. Tyler |
Abstract: | A previous review summarized research prior to 2004 carried out on the bioactive host-defense peptides contained in the skin secretions of Australian anurans (frogs and toads). This review covers the extension of that research from 2004 to 2012, and includes membrane-active peptides (including antibacterial, anticancer, antifungal and antiviral peptides) together with the mechanisms by which these peptides interact with model membranes, peptides that may be classified as "neuropeptides" (including smooth muscle active peptides, opioids and immunomodulators) and peptides which inhibit the formation of nitric oxide from neuronal nitric oxide synthase. The review discusses the outcome of cDNA sequencing of signal-spacer-active peptides from an evolutionary viewpoint, and also lists those peptides for which activities have not been found to this time. |
Keywords: | Australian frogs and toads: Crinia, Cyclorana, Limnodynastes, Litoria, Uperoleia Mass spectrometry Nuclear magnetic resonance spectroscopy Membrane-active peptides “Neuropeptides” and related species Ca2+ calmodulin complexes Neuronal nitric oxide synthase cDNA sequencing |
Rights: | Copyright © 2012 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.peptides.2012.06.017 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1016/j.peptides.2012.06.017 |
Appears in Collections: | Aurora harvest Chemistry publications |
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