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Type: Journal article
Title: Cognitive functioning in children and adults with nonsyndromal cleft lip and/or palate: a meta-analysis
Author: Roberts, R.
Mathias, J.
Wheaton, P.
Citation: Journal of Pediatric Psychology, 2012; 37(7):786-797
Publisher: Oxford Univ Press Inc
Issue Date: 2012
ISSN: 0146-8693
Statement of
Rachel M. Roberts, Jane L. Mathias, and Patricia Wheaton
Abstract: Objective: To provide a meta-analysis of research that has examined the cognitive functioning of children and adults with cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP). Methods: Data from 29 studies, which compared persons with a cleft to a control group on tests of cognitive functioning, were analyzed. The data were obtained from 1,546 persons with cleft and 279,805 controls. Results: Participants with a cleft performed significantly worse on 7 cognitive domains. However, the only moderate and significant deficit, which was based on nonheterogeneous study findings and not subject to publication bias, was in the language domain. CL, CP, and CLP were all associated with cognitive impairments, although the profiles for the groups differed. Conclusions:  Cross-sectional studies suggest that persons with clefts experience poorer cognitive functioning across a range of domains, although large-scale longitudinal studies are needed to more definitively differentiate outcomes by cleft type.
Keywords: Cleft lip; cleft lip and palate; cleft palate; cognitive; meta-analysis
Rights: © The Author 2012
RMID: 0020121481
DOI: 10.1093/jpepsy/jss052
Appears in Collections:Psychology publications

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