Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/74862
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Type: Journal article
Title: Prevalence of coronary heart disease and cardiovascular risk factors in a national cross-sectional cohort study of systemic sclerosis
Author: Ngian, G.
Sahhar, J.
Proudman, S.
Stevens, W.
Wicks, I.
Van Doornum, S.
Citation: ARD online, 2012; 71(12):1980-1983
Publisher: BMJ Group
Issue Date: 2012
ISSN: 1468-2060
1468-2060
Statement of
Responsibility: 
Gene-Siew Ngian, Joanne Sahhar, Susanna M Proudman, Wendy Stevens, Ian P Wicks, Sharon Van Doornum
Abstract: OBJECTIVES To determine the prevalence of coronary heart disease (CHD) and cardiovascular risk factors in a well-characterised cohort of systemic sclerosis (SSc) patients, and to compare this with the general population. METHODS A cross-sectional study of the prevalence of CHD and cardiovascular risk factors in participants in the Australian Scleroderma Cohort Study was performed. Controls were drawn from the 2007–8 National Health Survey (NHS) and the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). OR and 95% CI were calculated to determine the prevalence of CHD and cardiovascular risk factors in SSc patients compared with controls. RESULTS Data were available for 850 SSc patients (86% female), 15 787 NHS participants (53% female) and 8802 AusDiab participants (56% female). Adjusted for age and gender, the OR of CHD in SSc patients was 1.9 (95% CI 1.4 to 2.4) compared with controls from AusDiab and 2.0 (95% CI 1.5 to 2.5) compared with controls from the NHS. The OR of CHD increased to 3.2 (95% CI 2.3 to 4.5) for SSc patients compared with controls from AusDiab after further adjustment for cardiovascular risk factors. Hypercholesterolaemia, diabetes mellitus and obesity were significantly less prevalent in the SSc cohort than in AusDiab. Within the SSc cohort, the presence of pulmonary arterial hypertension was associated with CHD. CONCLUSIONS This is the first report of an increased prevalence of CHD in SSc patients. Further studies are required to determine the relative contribution of scleroderma-specific factors such as microvascular disease to the development of CHD.
Keywords: Humans; Cardiovascular Diseases; Coronary Disease; Scleroderma, Systemic; Health Surveys; Prevalence; Risk Factors; Cohort Studies; Cross-Sectional Studies; Adult; Aged; Middle Aged; Australia; Female; Male
Rights: Copyright status unknown
RMID: 0020122588
DOI: 10.1136/annrheumdis-2011-201176
Grant ID: http://purl.org/au-research/grants/nhmrc/1023407
Appears in Collections:Medicine publications

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