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|Title:||Enzyme activity assays within microstructured optical fibers enabled by automated alignment|
|Citation:||Biomedical Optics Express, 2012; 3(12):1-10|
|Publisher:||Optical Society of America|
|Stephen C. Warren-Smith, Guiying Nie, Erik P. Schartner, Lois A. Salamonsen, and Tanya M. Monro|
|Abstract:||A fluorescence-based enzyme activity assay has been demonstrated within a small-core microstructured optical fiber (MOF) for the first time. To achieve this, a reflection-based automated alignment system has been developed, which uses feedback and piezoelectric actuators to maintain optical alignment. The auto-alignment system provides optical stability for the time required to perform an activity assay. The chosen assay is based on the enzyme proprotein convertase 5/6 (PC6) and has important applications in women's health.|
|Keywords:||(060.2370) Fiber optics sensors; (060.4005) Microstructured fibers; (280.1415) Biological sensing and sensors|
|Rights:||© 2012 OSA|
|Appears in Collections:||IPAS publications|
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