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https://hdl.handle.net/2440/7609
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Type: | Journal article |
Title: | Mechanism of gastroesophageal reflux in premature infants with chronic lung disease |
Author: | Omari, T. Barnett, C. Snel, A. Davidson, G. Haslam, R. Bakewell, M. Dent, J. |
Citation: | Journal of Pediatric Surgery, 1999; 34(12):1795-1798 |
Publisher: | W B SAUNDERS CO-ELSEVIER INC |
Issue Date: | 1999 |
ISSN: | 0022-3468 1531-5037 |
Statement of Responsibility: | T. Omari, C. Barnett, A. Snel, G. Davidson, R. Haslam, M. Bakewell, and J. Dent |
Abstract: | <h4>Background/purpose</h4>The aim of this study was to characterize the motor events responsible for gastroesophageal reflux (GER) and esophageal acid clearance in a cohort of preterm infants with chronic lung disease (CLD).<h4>Methods</h4>Esophageal motility was recorded for 2 to 3 hours postprandially in 14 preterm infants with mild-moderate or moderate-severe CLD at 33 to 39 weeks postmenstrual age using a sleeve-side hole micromanometric assembly into which a pH probe had been installed.<h4>Results</h4>Twenty-six acid GER episodes were recorded by pH probe. Of these, 22 (85%) were associated with transient lower esophageal sphincter (LES) relaxation. Transient LES relaxations were significantly longer in duration than single swallows (13.7 seconds v 4.6 seconds, P < .001) and had lower nadir pressures (1.1 mm Hg v 2.5 mm Hg, P < .001). During periods of esophageal acidification (pH below 4), peristaltic esophageal body pressure wave sequences cleared acid refluxate more effectively than nonperistaltic pressure wave sequences.<h4>Conclusions</h4>In preterm infants with CLD, transient LES relaxations are the predominant mechanism underlying GER, and esophageal clearance mechanisms are fully functional, which is similar to that seen in healthy preterm infants. |
Keywords: | Chronic lung disease preterm neonate acid gastroesophageal reflux esophageal motility esophageal acid clearance transient lower esophageal sphincter relaxation. |
Rights: | Copyright © 1999 Published by Elsevier Inc. |
DOI: | 10.1016/S0022-3468(99)90315-9 |
Published version: | http://dx.doi.org/10.1016/s0022-3468(99)90315-9 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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