Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/76265
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Pathophysiology and natural history of anorectal sequelae following radiation therapy for carcinoma of the prostate
Author: Yeoh, E.
Holloway, R.
Fraser, R.
Botten, R.
Di Matteo, A.
Butters, J.
Citation: International Journal of Radiation: Oncology - Biology - Physics, 2012; 84(5):E593-E599
Publisher: Elsevier Science Inc
Issue Date: 2012
ISSN: 0360-3016
1879-355X
Statement of
Responsibility: 
Eric K. Yeoh, Richard H. Holloway, Robert J. Fraser, Rochelle J. Botten, Addolorata C. Di Matteo, Julie Butters
Abstract: <h4>Purpose</h4>To characterize the prevalence, pathophysiology, and natural history of chronic radiation proctitis 5 years following radiation therapy (RT) for localized carcinoma of the prostate.<h4>Methods and materials</h4>Studies were performed in 34 patients (median age 68 years; range 54-79) previously randomly assigned to either 64 Gy in 32 fractions over 6.4 weeks or 55 Gy in 20 fractions over 4 weeks RT schedule using 2- and later 3-dimensional treatment technique for localized prostate carcinoma. Each patient underwent evaluations of (1) gastrointestinal (GI) symptoms (Modified Late Effects in Normal Tissues Subjective, Objective, Management and Analytic scales including effect on activities of daily living [ADLs]); (2) anorectal motor and sensory function (manometry and graded balloon distension); and (3) anal sphincteric morphology (endoanal ultrasound) before RT, at 1 month, and annually for 5 years after its completion.<h4>Results</h4>Total GI symptom scores increased after RT and remained above baseline levels at 5 years and were associated with reductions in (1) basal anal pressures, (2) responses to squeeze and increased intra-abdominal pressure, (3) rectal compliance and (4) rectal volumes of sensory perception. Anal sphincter morphology was unchanged. At 5 years, 44% and 21% of patients reported urgency of defecation and rectal bleeding, respectively, and 48% impairment of ADLs. GI symptom scores and parameters of anorectal function and anal sphincter morphology did not differ between the 2 RT schedules or treatment techniques.<h4>Conclusions</h4>Five years after RT for prostate carcinoma, anorectal symptoms continue to have a significant impact on ADLs of almost 50% of patients. These symptoms are associated with anorectal dysfunction independent of the RT schedules or treatment techniques reported here.
Keywords: Rectum
Humans
Carcinoma
Prostatic Neoplasms
Proctitis
Radiation Injuries
Ultrasonography
Reflex
Radiotherapy Dosage
Activities of Daily Living
Prospective Studies
Sensation
Pressure
Time Factors
Aged
Middle Aged
Anal Canal
Male
Rights: Crown copyright © 2012 Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ijrobp.2012.06.032
Published version: http://dx.doi.org/10.1016/j.ijrobp.2012.06.032
Appears in Collections:Aurora harvest 4
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.