Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76433
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Type: Journal article
Title: Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia
Author: Yin, O.
Giles, F.
Baccarani, M.
le Coutre, P.
Chiparus, O.
Gallagher, N.
Saglio, G.
Hughes, T.
Hochhaus, A.
Kantarjian, H.
Larson, R.
Citation: Cancer Chemotherapy and Pharmacology, 2012; 70(2):345-350
Publisher: Springer
Issue Date: 2012
ISSN: 0344-5704
1432-0843
Statement of
Responsibility: 
Ophelia Q. P. Yin, Frank J. Giles, Michele Baccarani, Philipp le Coutre, Ovidiu Chiparus, Neil Gallagher, Giuseppe Saglio, Timothy P. Hughes, Andreas Hochhaus, Hagop M. Kantarjian, Richard A. Larson
Abstract: The impact of proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2 blockers) on the efficacy of nilotinib was evaluated.Retrospective analyses were performed in patients with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP; N = 492) and in patients with imatinib-resistant or imatinib-intolerant Ph+ CML-CP (N = 256) treated with nilotinib.In the newly diagnosed population, 87 (17.7 %) and 49 (10.0 %) patients received PPIs and H2 blockers, respectively. Major molecular response at 12 months was achieved by 59 (49.6 %) patients who received at least one PPI or H2 blocker (n = 119) and 153 (41.0 %) patients who did not receive any comedication (n = 373; P = 0.13). PPIs and H2 blockers were used by 77 (30.1 %) and 17 (6.6 %) patients with imatinib-resistant or imatinib-intolerant CML-CP, respectively. Major cytogenetic response by 12 months was achieved by 55 (64.0 %) patients who received at least one PPI or H2 blocker (n = 86) versus 98 (57.6 %) patients who did not receive any comedication (n = 170; P = 0.40); 39 (45.3 %) versus 65 (38.2 %), respectively, achieved complete cytogenetic response by 12 months (P = 0.34). Similar findings were observed in patients who received comedication for >50 % of the time on nilotinib therapy. Nilotinib steady-state trough concentration was not affected by the presence of PPIs or H2 blockers.Concurrent use of PPIs or H2 blockers did not affect the pharmacokinetics and efficacy of nilotinib in patients with Ph+ CML-CP.
Keywords: Nilotinib; Drug–drug interactions; Proton pump inhibitors; H2 blockers; Chronic myeloid leukemia
Rights: © Springer-Verlag 2012
RMID: 0020121423
DOI: 10.1007/s00280-012-1881-3
Appears in Collections:Medicine publications

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