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|Title:||bcl-w, a novel member of the bcl-2 family, promotes cell survival|
|Citation:||Oncogene, 1996; 13(4):665-675|
|Gibson, L ; Holmgreen, S P ; Huang, D C ; Bernard, O ; Copeland, N G ; Jenkins, N A ; Sutherland, G R ; Baker, E ; Adams, J M ; Cory, S|
|Abstract:||The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene.|
|Keywords:||Chromosomes, Human, Pair 14; Animals; Mice, Inbred C57BL; Humans; Mice; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; DNA, Complementary; Chromosome Mapping; Cloning, Molecular; Cell Survival; Amino Acid Sequence; Base Sequence; Sequence Homology, Amino Acid; Multigene Family; Molecular Sequence Data; Female; Male; Apoptosis Regulatory Proteins|
|Appears in Collections:||Paediatrics publications|
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