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|Title:||IgG4-related orbital disease: a meta-analysis and review|
|Citation:||Acta Ophthalmologica, 2012; online(8):1-7|
|Nicholas Andrew, Daniel Kearney and Dinesh Selva|
|Abstract:||IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.|
|Keywords:||dacryoadenitis; IgG4; IgG4-related disease; IgG4-related orbital disease; orbital; review|
|Rights:||© 2012 The Authors.|
|Appears in Collections:||Opthalmology & Visual Sciences publications|
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