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https://hdl.handle.net/2440/77749
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Type: | Journal article |
Title: | Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review |
Author: | Sinnollareddy, M. Peake, S. Roberts, M. Lipman, J. Roberts, J. |
Citation: | International Journal of Antimicrobial Agents, 2012; 39(1):1-10 |
Publisher: | Elsevier Science BV |
Issue Date: | 2012 |
ISSN: | 0924-8579 1872-7913 |
Statement of Responsibility: | Mahipal Sinnollareddy, Sandra L. Peake, Michael S. Roberts, Jeffrey Lipman, Jason A. Roberts |
Abstract: | The prevalence of invasive fungal infections (IFIs) caused by Candida spp. is increasing in critically ill patients. Recent development of new antifungal agents has significantly contributed to the successful treatment of IFIs. However, the pharmacokinetics of antifungal agents can be altered in a number of disease states, including critical illness. Therefore, doses established in healthy volunteers and other patient groups may not be appropriate for the critically ill. Moreover, inadequate dosing may contribute to treatment failure and the emergence of resistance. This systematic review provides a critical analysis of the pharmacokinetics of antifungal agents in the critically ill and their relevance to dosing requirements in clinical practice. Based on the limited data available, dosing of some antifungal agents may have to be adjusted in critically ill patients with conserved renal function as well as in those requiring renal replacement therapy. Further research to confirm the appropriateness of current dosing strategies to attain the appropriate pharmacodynamic targets is recommended. |
Keywords: | Pharmacokinetics Pharmacodynamics Antifungal agents Critically ill Renal replacement therapy |
Rights: | © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
DOI: | 10.1016/j.ijantimicag.2011.07.013 |
Published version: | http://dx.doi.org/10.1016/j.ijantimicag.2011.07.013 |
Appears in Collections: | Aurora harvest Medicine publications |
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