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https://hdl.handle.net/2440/7782
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dc.contributor.author | Moore, L. | - |
dc.contributor.author | Bourne, A. | - |
dc.contributor.author | Moore, D. | - |
dc.contributor.author | Preston, H. | - |
dc.contributor.author | Byard, R. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 1997; 17(4):601-610 | - |
dc.identifier.issn | 1077-1042 | - |
dc.identifier.issn | 1087-6529 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7782 | - |
dc.description.abstract | Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child. | - |
dc.description.statementofresponsibility | Lynette Moore; Anthony J. Bourne; BS David J. Moore; BS Henry Preston; BS Roger W. Byard | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS | - |
dc.source.uri | http://dx.doi.org/10.1080/107710497174570 | - |
dc.subject | Giant Cells | - |
dc.subject | Humans | - |
dc.subject | Carcinoma, Hepatocellular | - |
dc.subject | Liver Neoplasms | - |
dc.subject | Hepatitis | - |
dc.subject | Liver Cirrhosis | - |
dc.subject | Jaundice, Neonatal | - |
dc.subject | Biopsy, Needle | - |
dc.subject | Flow Cytometry | - |
dc.subject | Fatal Outcome | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant, Newborn | - |
dc.subject | Female | - |
dc.title | Hepatocellular carcinoma following neonatal hepatitis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/713601311 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Byard, R. [0000-0002-0524-5942] | - |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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