Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7886
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSutherland, G.en
dc.contributor.authorBaker, E.en
dc.contributor.authorRichards, R.en
dc.date.issued1998en
dc.identifier.citationTrends in Genetics, 1998; 14(12):501-506en
dc.identifier.issn0168-9525en
dc.identifier.issn1362-4555en
dc.identifier.urihttp://hdl.handle.net/2440/7886-
dc.description.abstractRare fragile sites on chromosomes are the archetypal dynamic mutations. They involve large expansions of the microsatellite CCG or AT-rich minisatellites. The mutation process is an increase in repeat-unit number from within a normal range, through a premutation range, up to full mutation where the fragile site is expressed. Full mutations can inactivate genes and are regions of genomic instability. Common fragile sites, in particular, might have a role in oncogensis by facilitating gene inactivation through chromosomal deletion or amplification, but this requires further exploration. The mechanisms behind the changes that give rise to the cytogenetic manifestation of chromosomal fragility are now beginning to be understood.en
dc.language.isoenen
dc.publisherELSEVIER SCIENCE LONDONen
dc.subjectHumans; Neoplasms; Chromosome Fragility; Chromosome Fragile Sites; Intellectual Disabilityen
dc.titleFragile sites still breaking [Review]en
dc.typeJournal articleen
dc.identifier.rmid0030005360en
dc.identifier.doi10.1016/S0168-9525(98)01628-Xen
dc.identifier.pubid69366-
pubs.library.collectionPaediatrics publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.