Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/79055
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Type: Journal article
Title: Widespread horizontal transfer of retrotransposons
Author: Walsh, A.
Kortschak, R.
Gardner, M.
Bertozzi, T.
Adelson, D.
Citation: Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(3):1012-1016
Publisher: Natl Acad Sciences
Issue Date: 2013
ISSN: 0027-8424
1091-6490
Statement of
Responsibility: 
Ali Morton Walsh, R. Daniel Kortschak, Michael G. Gardner, Terry Bertozzi, and David L. Adelson
Abstract: In higher organisms such as vertebrates, it is generally believed that lateral transfer of genetic information does not readily occur, with the exception of retroviral infection. However, horizontal transfer (HT) of protein coding repetitive elements is the simplest way to explain the patchy distribution of BovB, a long interspersed element (LINE) about 3.2 kb long, that has been found in ruminants, marsupials, squamates, monotremes, and African mammals. BovB sequences are a major component of some of these genomes. Here we show that HT of BovB is significantly more widespread than believed, and we demonstrate the existence of two plausible arthropod vectors, specifically reptile ticks. A phylogenetic tree built from BovB sequences from species in all of these groups does not conform to expected evolutionary relationships of the species, and our analysis indicates that at least nine HT events are required to explain the observed topology. Our results provide compelling evidence for HT of genetic material that has transformed vertebrate genomes.
Keywords: transposon; interspersed repeat
Rights: © Authors
RMID: 0020124689
DOI: 10.1073/pnas.1205856110
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute publications

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