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|Title:||Thyrotropin releasing hormone (TRH) and lung maturation: Does 200mcg TRH provide effective stimulation to the preterm pituitary gland compared with 400mcg?|
|Citation:||American Journal of Obstetrics and Gynaecology, 1995; 173(1):719-733|
|Caroline Crowther, Ross Haslam, Janet Hiller, Terry McGee, Richard Ryall, Jeffrey Robinson|
|Abstract:||OBJECTIVE:Our purpose was to compare the response of the fetal pituitary-thyroid axis to 200 and 400 micrograms of thyrotropin-releasing hormone administered to the mother immediately before delivery with a control group. STUDY DESIGN:A randomized controlled trial was conducted of 26 women at gestational ages between 24 weeks and 33 weeks 6 days who had received one or more doses of betamethasone who were expected to be delivered within 1 to 4 hours. Women received either 200 or 400 micrograms of thyrotropin-releasing hormone or were in the control group. RESULTS:Thyroid-stimulating hormone determinations on cord blood had a higher mean level in both treatment groups compared with the control group. No differences were seen in cord blood results between the two treatment groups for thyroid-stimulating hormone, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine, and prolactin levels. The only other differences found were in a higher level in total thyroxine and a lower level of free thyroxine in the 400 micrograms thyrotropin-releasing hormone group compared with the 200 micrograms group in the 48-hour blood determinations. CONCLUSION:Both 200 and 400 micrograms of thyrotropin-releasing hormone provided fetal pituitary stimulation, as reflected in fetal thyroid-stimulating hormone levels in cord blood, and both gave significantly higher levels compared with a control group.|
|Keywords:||Pituitary Gland; Fetal Blood; Humans; Prolactin; Thyrotropin; Triiodothyronine; Thyroxine; Gestational Age; Pregnancy; Dose-Response Relationship, Drug; Adult; Female; Thyrotropin-Releasing Hormone|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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