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Type: Journal article
Title: Thyrotropin releasing hormone (TRH) and lung maturation: Does 200mcg TRH provide effective stimulation to the preterm pituitary gland compared with 400mcg?
Author: Crowther, C.
Haslam, R.
Hiller, J.
McGee, T.
Ryall, R.
Robinson, J.
Citation: American Journal of Obstetrics and Gynaecology, 1995; 173(1):719-733
Publisher: C.V. Mosby
Issue Date: 1995
ISSN: 0002-9378
Statement of
Caroline Crowther, Ross Haslam, Janet Hiller, Terry McGee, Richard Ryall, Jeffrey Robinson
Abstract: OBJECTIVE:Our purpose was to compare the response of the fetal pituitary-thyroid axis to 200 and 400 micrograms of thyrotropin-releasing hormone administered to the mother immediately before delivery with a control group. STUDY DESIGN:A randomized controlled trial was conducted of 26 women at gestational ages between 24 weeks and 33 weeks 6 days who had received one or more doses of betamethasone who were expected to be delivered within 1 to 4 hours. Women received either 200 or 400 micrograms of thyrotropin-releasing hormone or were in the control group. RESULTS:Thyroid-stimulating hormone determinations on cord blood had a higher mean level in both treatment groups compared with the control group. No differences were seen in cord blood results between the two treatment groups for thyroid-stimulating hormone, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine, and prolactin levels. The only other differences found were in a higher level in total thyroxine and a lower level of free thyroxine in the 400 micrograms thyrotropin-releasing hormone group compared with the 200 micrograms group in the 48-hour blood determinations. CONCLUSION:Both 200 and 400 micrograms of thyrotropin-releasing hormone provided fetal pituitary stimulation, as reflected in fetal thyroid-stimulating hormone levels in cord blood, and both gave significantly higher levels compared with a control group.
Keywords: Pituitary Gland; Fetal Blood; Humans; Prolactin; Thyrotropin; Triiodothyronine; Thyroxine; Gestational Age; Pregnancy; Dose-Response Relationship, Drug; Adult; Female; Thyrotropin-Releasing Hormone
RMID: 0030005351
DOI: 10.1016/0002-9378(95)90329-1
Appears in Collections:Obstetrics and Gynaecology publications

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