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https://hdl.handle.net/2440/7909
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dc.contributor.author | Crowther, C. | - |
dc.contributor.author | Haslam, R. | - |
dc.contributor.author | Hiller, J. | - |
dc.contributor.author | McGee, T. | - |
dc.contributor.author | Ryall, R. | - |
dc.contributor.author | Robinson, J. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | American Journal of Obstetrics and Gynecology, 1995; 173(1):719-733 | - |
dc.identifier.issn | 0002-9378 | - |
dc.identifier.issn | 1097-6868 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7909 | - |
dc.description.abstract | <h4>Objective</h4>Our purpose was to compare the response of the fetal pituitary-thyroid axis to 200 and 400 micrograms of thyrotropin-releasing hormone administered to the mother immediately before delivery with a control group.<h4>Study design</h4>A randomized controlled trial was conducted of 26 women at gestational ages between 24 weeks and 33 weeks 6 days who had received one or more doses of betamethasone who were expected to be delivered within 1 to 4 hours. Women received either 200 or 400 micrograms of thyrotropin-releasing hormone or were in the control group.<h4>Results</h4>Thyroid-stimulating hormone determinations on cord blood had a higher mean level in both treatment groups compared with the control group. No differences were seen in cord blood results between the two treatment groups for thyroid-stimulating hormone, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine, and prolactin levels. The only other differences found were in a higher level in total thyroxine and a lower level of free thyroxine in the 400 micrograms thyrotropin-releasing hormone group compared with the 200 micrograms group in the 48-hour blood determinations.<h4>Conclusion</h4>Both 200 and 400 micrograms of thyrotropin-releasing hormone provided fetal pituitary stimulation, as reflected in fetal thyroid-stimulating hormone levels in cord blood, and both gave significantly higher levels compared with a control group. | - |
dc.description.statementofresponsibility | Caroline Crowther, Ross Haslam, Janet Hiller, Terry McGee, Richard Ryall, Jeffrey Robinson | - |
dc.language.iso | en | - |
dc.publisher | C.V. Mosby | - |
dc.source.uri | http://dx.doi.org/10.1016/0002-9378(95)90329-1 | - |
dc.subject | Pituitary Gland | - |
dc.subject | Fetal Blood | - |
dc.subject | Humans | - |
dc.subject | Prolactin | - |
dc.subject | Thyrotropin | - |
dc.subject | Triiodothyronine | - |
dc.subject | Thyroxine | - |
dc.subject | Gestational Age | - |
dc.subject | Pregnancy | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Thyrotropin-Releasing Hormone | - |
dc.title | Thyrotropin releasing hormone (TRH) and lung maturation: Does 200mcg TRH provide effective stimulation to the preterm pituitary gland compared with 400mcg? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/0002-9378(95)90329-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Crowther, C. [0000-0002-9079-4451] | - |
dc.identifier.orcid | Hiller, J. [0000-0002-8532-4033] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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