Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/79742
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dc.contributor.authorWu, T.-
dc.contributor.authorBound, M.-
dc.contributor.authorStandfield, S.-
dc.contributor.authorGedulin, B.-
dc.contributor.authorJones, K.-
dc.contributor.authorHorowitz, M.-
dc.contributor.authorRayner, C.-
dc.date.issued2013-
dc.identifier.citationDiabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2013; 15(5):474-477-
dc.identifier.issn1462-8902-
dc.identifier.issn1463-1326-
dc.identifier.urihttp://hdl.handle.net/2440/79742-
dc.description.abstractGlucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.-
dc.description.statementofresponsibilityT. Wu, M. J. Bound, S. D. Standfield, B.Gedulin, K. L. Jones, M. Horowitz & C. K. Rayner-
dc.language.isoen-
dc.publisherBlackwell Publishing Ltd-
dc.rights© 2012 Blackwell Publishing Ltd-
dc.source.urihttp://dx.doi.org/10.1111/dom.12043-
dc.subjectbile salt-
dc.subjectglucagon-like peptide 1-
dc.subjectpeptide YY-
dc.titleEffects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans-
dc.typeJournal article-
dc.identifier.doi10.1111/dom.12043-
pubs.publication-statusPublished-
dc.identifier.orcidWu, T. [0000-0003-1656-9210]-
dc.identifier.orcidBound, M. [0000-0003-0211-5832]-
dc.identifier.orcidJones, K. [0000-0002-1155-5816]-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]-
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