Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8010
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Type: Journal article
Title: Understanding and managing disturbances in insulin metabolism and body weight in women with polycystic ovary syndrome
Author: Moran, L.
Norman, R.
Citation: Best Practice and Research: Clinical Obstetrics and Gynaecology, 2004; 18(5):719-736
Publisher: Bailliere Tindall
Issue Date: 2004
ISSN: 1521-6934
1532-1932
Statement of
Responsibility: 
L. Moran and R. J. Norman
Abstract: Polycystic ovary syndrome (PCOS) is a common clinical and metabolic condition in women of reproductive age. It is associated with short-term reproductive and long-term metabolic dysfunction. Treatment has traditionally focused on fertility and hormonal therapy. However, general obesity, central obesity and insulin resistance are strongly implicated in its aetiology and improving these factors has proved highly successful in some clinical situations, reducing the need for costly assisted reproduction. A low-fat, high-carbohydrate diet is thought to improve insulin sensitivity, aid in weight loss and reduction of metabolic and reproductive symptoms and improve the long-term maintenance of a reduced weight. However, there has been recent community interest in adopting a protocol advocating a moderate increase in dietary protein for improving weight loss and PCOS symptoms. Altering the glycaemic index of the diet has also received considerable attention as a regime for promoting satiety and reducing metabolic risk factors for type 2 diabetes mellitus and cardiovascular disease. Exercise and other lifestyle changes are essential for altering the short- and long-term effects of PCOS. It is vital that the efficacy of these strategies is assessed so that accurate medical and dietetic advice can be given both to patients and to the health-care community.
Keywords: Dietary intervention
metformin and insulin resistance
obesity and overweight
polycystic ovary syndrome
DOI: 10.1016/j.bpobgyn.2004.05.003
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/623004/description#description
Published version: http://dx.doi.org/10.1016/j.bpobgyn.2004.05.003
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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