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Type: Journal article
Title: Diabetic gastroparesis: Recent insights into pathophysiology and implications for management
Author: Sebastian Thazhath, S.
Jones, K.
Horowitz, M.
Rayner, C.
Citation: Expert Review of Gastroenterology and Hepatology, 2013; 7(2):127-139
Publisher: Expert Reviews Ltd.
Issue Date: 2013
ISSN: 1747-4124
Statement of
Sony S Thazhath, Karen L Jones, Michael Horowitz and Christopher K Rayner
Abstract: Delayed gastric emptying affects a substantial proportion of patients with long-standing diabetes, and when associated with symptoms and/or disordered glycemic control, affects quality of life adversely. Important clinicopathological insights have recently been gained by the systematic analysis of gastric biopsies from patients with severe diabetic gastroparesis, which may stimulate the development of new therapies in the coming decade. Experience with prokinetic therapies and treatments, such as pyloric botulinum toxin injection and gastric electrical stimulation, has established that relief of symptoms does not correlate closely with acceleration of delayed gastric emptying, and that well-designed controlled trials are essential to determine the efficacy of emerging therapies.
Keywords: Humans; Gastroparesis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes Complications; Antiemetics; Neuromuscular Agents; Botulinum Toxins; Magnetic Resonance Imaging; Prognosis; Complementary Therapies; Electric Stimulation Therapy; Nutritional Status; Gastrointestinal Motility; Gastric Emptying; Muscle Contraction; Neural Stem Cells; Pain Management
Rights: Copyright status unknown
RMID: 0020124795
DOI: 10.1586/egh.12.82
Appears in Collections:Medicine publications

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