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dc.contributor.authorSelth, L.en
dc.contributor.authorTownley, S.en
dc.contributor.authorGillis, J.en
dc.contributor.authorTilley, W.en
dc.contributor.authorButler, L.en
dc.identifier.citationCirculating MicroRNAs. Methods and Protocols, 2013 / Ochiya, T. (ed./s), pp.235-246en
dc.description.abstractMicroRNAs (miRNAs) derived from the cell-free fractions of blood are emerging as useful noninvasive markers of cancer. However, many tumors display significant molecular heterogeneity, which is likely to be reflected in the circulating miRNA fingerprints associated with that pathology. One strategy to minimize such heterogeneity is to employ genetically engineered mouse models of human cancer. Here, we describe a method to profile miRNAs in the serum of a mouse model of prostate cancer, TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP), and discuss practical considerations for translating these potential biomarkers into a clinical setting.en
dc.description.statementofresponsibilityLuke A. Selth, Scott L. Townley, Joanna L. Gillis, Wayne D. Tilley, and Lisa M. Butleren
dc.rights© Springer Science+Business Media New York 2013en
dc.subjectCirculating; microRNA; Mouse model; Plasma; Prostate cancer; Serum; TRAMPen
dc.titleIdentification of prostate cancer-associated microRNAs in circulation using a mouse model of diseaseen
dc.typeBook chapteren
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidSelth, L. [0000-0002-4686-1418]en
dc.identifier.orcidTilley, W. [0000-0003-1893-2626]en
dc.identifier.orcidButler, L. [0000-0003-2698-3220]en
Appears in Collections:Medicine publications

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