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https://hdl.handle.net/2440/8132
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Type: | Journal article |
Title: | Preeclampsia: a couple's disease with maternal and fetal manifestations |
Author: | Dekker, G. Robillard, P. |
Citation: | Current Pharmaceutical Design, 2004; 11(6):699-710 |
Publisher: | Bentham Science Publ Ltd |
Issue Date: | 2004 |
ISSN: | 1381-6128 1873-4286 |
Abstract: | Preeclampsia still ranks as one of obstetrics major problems. Clinicians typically encounter preeclampsia as maternal disease with variable degrees of fetal involvement. More and more the unique immunogenetic maternal-paternal relationship is appreciated, and as such also the specific 'genetic conflict' that is characteristic of haemochorial placentation. From that perspective preeclampsia can also been seen as a disease of an individual couple with primarily maternal and fetal manifestations. Factors that are unique to a specific couple would include the length and type of sexual relationship, the maternal (decidual natural killer cells) acceptation of the invading cytotrophoblast (paternal HLA-C), and seminal levels of transforming growth factor-beta and probably other cytokines. The magnitude of the maternal response would be determined by factors including a maternal set of genes determining her characteristic inflammatory responsiveness, age, quality of her endothelium, obesity/insulin resistance and probably a whole series of susceptibility genes amongst which the thrombophilias received a lot of attention in recent years. |
Keywords: | fetal allograft hypertension immunology paternity preeclampsia |
DOI: | 10.2174/1381612053381828 |
Description (link): | http://www.bentham.org/cpd/index.htm |
Published version: | http://dx.doi.org/10.2174/1381612053381828 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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