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https://hdl.handle.net/2440/81727
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Type: | Journal article |
Title: | Randomized controlled trial of fish oil supplementation in pregnancy on childhood allergies |
Author: | Palmer, D. Sullivan, T. Gold, M. Prescott, S. Heddle, R. Gibson, R. Makrides, M. |
Citation: | Allergy, 2013; 68(11):1370-1376 |
Publisher: | Munksgaard Int Publ Ltd |
Issue Date: | 2013 |
ISSN: | 0105-4538 1398-9995 |
Statement of Responsibility: | D. J. Palmer, T. Sullivan, M. S. Gold, S. L. Prescott, R. Heddle, R. A. Gibson & M. Makrides |
Abstract: | <h4>Background</h4>Diets high in n-3 long chain polyunsaturated fatty acids (LCPUFA) may modulate the development of IgE-mediated allergic disease and have been proposed as a possible allergy prevention strategy. The aim of this study was to determine whether n-3 LCPUFA supplementation of pregnant women reduces IgE-mediated allergic disease in their children.<h4>Methods</h4>Follow-up of children (n = 706) at hereditary risk of allergic disease in the Docosahexaenoic Acid to Optimise Mother Infant Outcome randomized controlled trial. The intervention group (n = 368) was randomly allocated to receive fish oil capsules (providing 900 mg of n-3 LCPUFA daily) from 21 weeks' gestation until birth; the control group (n = 338) received matched vegetable oil capsules without n-3 LCPUFA. The diagnosis of allergic disease was made during medical assessments at 1 and 3 years of age.<h4>Results</h4>No differences were seen in the overall percentage of children with IgE-mediated allergic disease in the first 3 years of life between the n-3 LCPUFA and control groups (64/368 (17.3%) vs 76/338 (22.6%); adjusted relative risk 0.78; 95% CI 0.58-1.06; P = 0.11). Eczema was the most common allergic disease; 13.8% of children in the n-3 LCPUFA group had eczema with sensitization compared with 19.0% in the control group (adjusted relative risk 0.75; 95% CI 0.53-1.05; P = 0.10).<h4>Conclusions</h4>Overall, n-3 LCPUFA supplementation during pregnancy did not significantly reduce IgE-associated allergic disease in the first 3 years of life. Further studies should examine whether the nonsignificant reductions in IgE-associated allergies are of clinical and public health significance. |
Keywords: | allergy prevention eczema fatty acids pregnancy randomized controlled trial |
Rights: | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
DOI: | 10.1111/all.12233 |
Published version: | http://dx.doi.org/10.1111/all.12233 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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hdl_81727.pdf | Submitted version | 148.58 kB | Adobe PDF | View/Open |
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