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https://hdl.handle.net/2440/81961
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dc.contributor.author | Dorniak-Wall, T. | - |
dc.contributor.author | Grivell, R. | - |
dc.contributor.author | Dekker, G. | - |
dc.contributor.author | Hague, W. | - |
dc.contributor.author | Dodd, J. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Human Hypertension, 2014; 28(4):230-235 | - |
dc.identifier.issn | 0950-9240 | - |
dc.identifier.issn | 1476-5527 | - |
dc.identifier.uri | http://hdl.handle.net/2440/81961 | - |
dc.description.abstract | Pre-eclampsia is a significant health issue in pregnancy, complicating between 2-8% of pregnancies. L-arginine is an important mediator of vasodilation with a potential preventative role in pregnancy related hypertensive diseases. We aimed to systematically review randomised trials in the literature assessing the role of L-arginine in prevention and treatment of pre-eclampsia. We searched the Cochrane Controlled Trials Register, PUBMED, and the Australian and International Clinical Trials Registry, to identify randomised trials involving pregnant women where L-arginine was administered for pre-eclampsia to improve maternal and infant health outcomes. We identified eight randomised trials, seven of which were included. The methodological quality was fair, with a combined sample size of 884 women. For women at risk of pre-eclampsia, L-arginine was associated with a reduction in pre-eclampsia (RR: 0.34, 95% CI: 0.21-0.55), when compared with placebo and a reduction in risk of preterm birth (RR: 0.48 and 95% CI: 0.28 to 0.81). For women with established hypertensive disease, L-arginine was associated with a reduction in pre-eclampsia (RR: 0.21; 95% CI: 0.05-0.98). L-arginine may have a role in the prevention and/or treatment of pre-eclampsia. Further well-designed and adequately powered trials are warranted, both in women at risk of pre-eclampsia and in women with established disease. | - |
dc.description.statementofresponsibility | T Dorniak-Wall, RM Grivell, GA Dekker, W Hague, and JM Dodd | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2013 Macmillan Publishers Limited | - |
dc.source.uri | http://dx.doi.org/10.1038/jhh.2013.100 | - |
dc.subject | pregnancy | - |
dc.subject | L-arginine | - |
dc.subject | pre-eclampsia | - |
dc.subject | hypertensive disease | - |
dc.title | The role of L-arginine in the prevention and treatment of pre-eclampsia: a systematic review of randomised trials | - |
dc.type | Journal article | - |
dc.contributor.organisation | Robinson Institute | - |
dc.identifier.doi | 10.1038/jhh.2013.100 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grivell, R. [0000-0002-2447-6519] | - |
dc.identifier.orcid | Dekker, G. [0000-0002-7362-6683] | - |
dc.identifier.orcid | Hague, W. [0000-0002-5355-2955] | - |
dc.identifier.orcid | Dodd, J. [0000-0002-6363-4874] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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