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|Title:||Signalling by the βc family of cytokines|
|Other Titles:||Signalling by the beta c family of cytokines|
|Citation:||Cytokine & Growth Factor Reviews, 2013; 24(3):189-201|
|Publisher:||Elsevier Sci Ltd|
|Timothy R. Hercus, Urmi Dhagat, Winnie L.T. Kan, Sophie E. Broughton, Tracy L. Nero, Michelle Perugini, Jarrod J. Sandow, Richard J. D’Andrea, Paul G. Ekert, Timothy Hughes, Michael W. Parker, Angel F. Lopez|
|Abstract:||The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the βc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the βc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.|
|Keywords:||β Common receptor; Cytokines; Inflammation; Leukaemia; Signalling|
|Rights:||Crown Copyright © 2013 Published by Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Medicine publications|
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