Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8240
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Type: Journal article
Title: Lack of agreement between central venous pressure and pulmonary capillary wedge pressure in preeclampsia
Author: Bolte, A.
Dekker, G.
van Eyck, J.
van Schijndel, R.
van Geijn, H.
Citation: Hypertension in Pregnancy, 2000; 19(3):261-271
Publisher: Marcel Dekker Inc
Issue Date: 2000
ISSN: 1064-1955
1525-6065
Statement of
Responsibility: 
Antoinette C. Bolte, Gustaaf A. Dekker, Jim van Eyck, Rob Strack van Schijndel, and Herman P. van Geijn
Abstract: OBJECTIVE:To establish if agreement exists between central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP) measurements in severe hypertension in pregnancy as analyzed by tests of bias, precision, and 95% limits of agreement. METHODS:In a prospective study, CVP and PCWP data in 30 patients were collected by means of a pulmonary artery catheter from initiation of therapy until delivery. Patients with a diastolic blood pressure of more than 110 mm Hg were included. Correlation and agreement between CVP and PCWP before and after treatment were evaluated. RESULTS:The correlation coefficient (r) for CVP-PCWP data in 30 untreated patients was r = 0.64 (p = 0.0002) and for 256 pairs of posttreatment data, it was r = 0.53 (p < 0.0001). Linear regression and correlation for each individual patient in 29 patients with more than 3 measurements showed a significant correlation (p < 0.05) in 19 patients (66%). Correlation was poor (p > 0.05) in 10 patients (34%). The mean difference between PCWP and CVP was 3.5 +/- 2.6 mm Hg (limits of agreement: -1.6 to 8.7) in untreated patients. The mean difference between PCWP and CVP for 256 pairs of data derived posttreatment was 4.9 +/- 3.8 mm Hg (limits of agreement: -2.7 to 12. 5). CONCLUSION:Invasive measurements of CVP and PCWP were found to agree poorly. Until a reliable noninvasive method is available to measure left ventricular preload, PCWP is the measurement of choice when invasive hemodynamic monitoring is necessary in patients with severe preeclampsia.
Keywords: Humans; Pre-Eclampsia; Succinates; Gelatin; Monitoring, Physiologic; Linear Models; Sensitivity and Specificity; Prospective Studies; Pregnancy; Blood Pressure; Pulmonary Wedge Pressure; Central Venous Pressure; Diastole; Female; Bias
RMID: 0001001121
DOI: 10.1081/PRG-100101987
Appears in Collections:Obstetrics and Gynaecology publications

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