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Type: Journal article
Title: Hemodynamic and metabolic effects after nifedipine and ritodrine tocolysis
Author: Papatsonis, D.
van Geijn, H.
Bleker, O.
Ader, H.
Dekker, G.
Citation: International Journal of Gynecology & Obstetrics, 2003; 82(1):5-10
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2003
ISSN: 0020-7292
Statement of
D. N. M. Papatsonis, H. P. van Geijn, O. P. Bleker, H. J. Adèr and G. A. Dekker
Abstract: Objectives: The purpose of this study is to compare the hemodynamic and metabolic changes after ritodrine and nifedipine tocolysis. Methods: For an open randomized study, patients with preterm labor (N=185) were allocated to groups to receive ritodrine intravenously (N=90) or nifedipine orally (N=95). Results: The mean diastolic blood pressure was significantly lower in the ritodrine group 24 h (65±12 vs. 70±8, P=0.001) and 48 h (65±12 vs. 71±8, P=0.004) after starting tocolysis compared with the nifedipine group. Mean maternal heart rate was significantly higher in the ritodrine group 24 h (105±17 vs. 86±13, P<0.0001) and 48 h (100±21 vs. 85±12, P<0.0001) after starting tocolysis compared with the nifedipine group. Mean fasting glucose levels were higher (6.68±2.53 vs. 4.93±1.23, P=0.0016), while mean potassium levels were lower (3.52±0.84 vs. 3.81±0.45, P=0.04) in the ritodrine group 48 h after starting tocolysis compared with the nifedipine group. Conclusions: Use of nifedipine for preterm labor is associated with a lower incidence of adverse hemodynamic and metabolic changes compared with ritodrine after 24 and 48 h of tocolysis. In our opinion nifedipine is the preferred drug of choice for the treatment of preterm labor.
Keywords: Premature labor; Tocolysis; Nifedipine; Ritodrine
Rights: Copyright © 2003 International Federation of Gynecology and Obstetrics.
RMID: 0020030529
DOI: 10.1016/S0020-7292(03)00145-0
Appears in Collections:Obstetrics and Gynaecology publications

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