Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/82575
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Collaboration between CpG sites is needed for stable somatic inheritance of DNA methylation states |
Author: | Haerter, J. Lovkvist, C. Dodd, I. Sneppen, K. |
Citation: | Nucleic Acids Research, 2014; 42(4):2235-2244 |
Publisher: | Oxford Univ Press |
Issue Date: | 2014 |
ISSN: | 0305-1048 1362-4962 |
Statement of Responsibility: | Jan O. Haerter, Cecilia Lövkvist, Ian B. Dodd and Kim Sneppen |
Abstract: | Inheritance of 5-methyl cytosine modification of CpG (CG/CG) DNA sequences is needed to maintain early developmental decisions in vertebrates. The standard inheritance model treats CpGs as independent, with methylated CpGs maintained by efficient methylation of hemimethylated CpGs produced after DNA replication, and unmethylated CpGs maintained by an absence of de novo methylation. By stochastic simulations of CpG islands over multiple cell cycles and systematic sampling of reaction parameters, we show that the standard model is inconsistent with many experimental observations. In contrast, dynamic collaboration between CpGs can provide strong error-tolerant somatic inheritance of both hypermethylated and hypomethylated states of a cluster of CpGs, reproducing observed stable bimodal methylation patterns. Known recruitment of methylating enzymes by methylated CpGs could provide the necessary collaboration, but we predict that recruitment of demethylating enzymes by unmethylated CpGs strengthens inheritance and allows CpG islands to remain hypomethylated within a sea of hypermethylation. |
Keywords: | DNA Methylation CpG Islands Inheritance Patterns Models, Genetic |
Description: | Published online 27 November 2013 |
Rights: | © The Author(s) 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1093/nar/gkt1235 |
Published version: | http://dx.doi.org/10.1093/nar/gkt1235 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_82575.pdf | Published version | 19.22 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.