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|Title:||Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial|
Meyer-Gerspach, Anne C.
|Citation:||Obesity, 2013; 21(12):E660-E668|
|Publisher:||Nature Publishing Group|
|School/Discipline:||School of Medicine : Medicine|
|Robert E. Steinert, Ralph Peterli, Sylvia Keller, Anne C. Meyer-Gerspach, Jürgen Drewe, Thomas Peters and Christoph Beglinger|
|Abstract:||OBJECTIVE Increased delivery of bile acid salts (BA) to distal L-cells and altered TGR5 receptor activation may contribute to the early and substantial increases in gut peptide secretion seen after bariatric surgery. To further elucidate a potential role of BA in the secretion of GLP-1 and PYY, we analyzed plasma BA concentrations in 14 morbidly obese patients undergoing gastric bypass or sleeve gastrectomy in a prospective, randomized 1-year trial. DESIGN AND METHODS Patients received a standard test meal and blood was collected before and after eating, prior to, and 1 week, 3 months, and 12 months after surgery. RESULTS Pre-surgery, basal BA concentrations were significantly lower in bariatric patients than in healthy controls. One year post-surgery, bariatric patients expressed variably increased BA concentrations (gastric bypass patients ∼2 fold increase, P ≤ 0.05). However, whereas in both patient groups, marked increases in GLP-1 and PYY and improved glycemic control was seen already 1 week and 3 months post-surgery, changes in plasma BA followed a different pattern: basal and postprandial plasma BA concentrations increased much slower, more progressively with significant increases only 1-year post-surgery. CONCLUSIONS Based on these findings, BA do not appear to be key mediators of the early increase in GLP-1 and PYY response in post-bariatric patients.|
|Rights:||© 2013 The Obesity Society|
|Appears in Collections:||Medicine publications|
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