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https://hdl.handle.net/2440/8267
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Type: | Journal article |
Title: | Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition |
Author: | Moran, L. Noakes, M. Clifton, P. Wittert, G. Tomlinson, L. Galletly, C. Luscombe-Marsh, N. Norman, R. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2004; 89(7):3337-3344 |
Publisher: | Endocrine Society |
Issue Date: | 2004 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe and R. J. Norman |
Abstract: | Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (–144.1 ± 58.4 vs. –28.9 ± 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS. |
Keywords: | Humans Polycystic Ovary Syndrome Obesity Body Weight Insulin Peptide Hormones Blood Glucose Dietary Proteins Pain Measurement Caloric Restriction Diet Fasting Regression Analysis Patient Compliance Satiety Response Body Composition Homeostasis Postprandial Period Adult Middle Aged Female Ghrelin |
Description: | Copyright © 2004 by The Endocrine Society |
DOI: | 10.1210/jc.2003-031583 |
Published version: | http://jcem.endojournals.org/cgi/content/abstract/89/7/3337 |
Appears in Collections: | Aurora harvest Medicine publications Obstetrics and Gynaecology publications Psychiatry publications |
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