Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8342
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dc.contributor.author | Brannstrom, M. | - |
dc.contributor.author | Bonello, N. | - |
dc.contributor.author | Norman, R. | - |
dc.contributor.author | Robertson, S. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Journal of Reproductive Immunology, 1995; 29(3):265-270 | - |
dc.identifier.issn | 0165-0378 | - |
dc.identifier.issn | 1872-7603 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8342 | - |
dc.description.abstract | To investigate the effect of systemic neutrophil depletion on ovulation rate, rats were synchronised with eCG and hCG, and concurrently were administered neutrophil-specific, cytotoxic RP-3 monoclonal antibody (mAb), or an irrelevant, class-matched mAb. Neutrophils in the peripheral blood and in the thecal-luteal area of corpora lutea were detected by immunohistochemical analysis with the neutrophil-specific mAb MCA149 and were found to be reduced in number by 70% and 38% respectively following RP-3 treatment compared to the control group. Ovulation rate, as assessed by counting the number of oocytes in the ampullary region of the oviduct 20 h after hCG administration, was found to be reduced by 27% in the neutrophil-depleted rats. This result provides further evidence that neutrophilic granulocytes play an active role in ovulation in the rat. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Biomedical Press | - |
dc.source.uri | http://dx.doi.org/10.1016/0165-0378(95)00941-d | - |
dc.subject | Neutrophils | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Antibodies, Monoclonal | - |
dc.subject | Ovulation | - |
dc.subject | Female | - |
dc.title | Reduction of ovulation rate in the rat by administration of a neutrophil-depleting monoclonal antibody | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/0165-0378(95)00941-D | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Norman, R. [0000-0002-3118-3896] | - |
dc.identifier.orcid | Robertson, S. [0000-0002-9967-0084] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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