Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84640
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Type: Journal article
Title: Prediction models in women with postmenopausal bleeding: a systematic review
Author: van Hanegem, N.
Breijer, M.
Opmeer, B.
Mol, B.
Timmermans, A.
Citation: Women's Health, 2012; 8(3):251-262
Publisher: Future Medicine
Issue Date: 2012
ISSN: 1745-5057
1745-5065
Statement of
Responsibility: 
Nehalennia van Hanegem, Maria C Breijer, Brent C Opmeer, Ben WJ Mol & Anne Timmermans
Abstract: Postmenopausal bleeding is associated with an elevated risk of having endometrial cancer. The aim of this review is to give an overview of existing prediction models on endometrial cancer in women with postmenopausal bleeding. In a systematic search of the literature, we identified nine prognostic studies, of which we assessed the quality, the different phases of development and their performance. From these data, we identified the most important predictor variables. None of the detected models completed external validation or impact analysis. Models including power Doppler showed best performance in internal validation, but Doppler in general gynecological practice is not easily accessible. We can conclude that we have indications that the first step in the approach of women with postmenopausal bleeding should be to distinguish between women with low risk versus high risk of having endometrial carcinoma and the next step would be to refer patients for further (invasive) testing.
Keywords: Humans; Endometrial Neoplasms; Uterine Hemorrhage; Postmenopause; Decision Support Techniques; Female
Rights: Copyright status unknown
RMID: 0020136881
DOI: 10.2217/whe.12.10
Appears in Collections:Obstetrics and Gynaecology publications

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