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Type: Journal article
Title: Long-term outcomes after adjunctive topical 5-flurouracil or mitomycin C for the treatment of surgically excised, localized ocular surface squamous neoplasia
Author: Bahrami, B.
Greenwell, T.
Muecke, J.
Citation: Clinical and Experimental Ophthalmology, 2014; 42(4):317-322
Publisher: Blackwell Publishing
Issue Date: 2014
ISSN: 1442-6404
Statement of
Bobak Bahrami, Timothy Greenwell and James S Muecke
Abstract: Background - To report rates of recurrence and complications of localized ocular surface squamous neoplasia treated with 5-fluorouracil or mitomycin C as adjunctive treatment to surgical excision. Design - Long-term follow up of two prospective, non-comparative interventional case series. Participants - One hundred fifty-three eyes with histologically confirmed localized, non-invasive ocular surface squamous neoplasia. 89 eyes were treated with adjuvant 5-fluorouracil and 64 eyes were treated with adjuvant mitomycin C. Methods - Following surgical excision±cryotherapy patients received topical 5-fluorouracil 1% four times daily for two weeks or topical mitomycin C 0.04% four times daily for two to three 1-week cycles. Main Outcome Measures - Ocular surface squamous neoplasia recurrence, complications of therapy and compliance. Results - Median follow up was 33.6 (range 12–84) months and 57.9 (range 12–160) months in 5-fluorouracil and mitomycin C groups, respectively. There was one recurrence in the 5-fluorouracil group and no recurrences in the mitomycin C group. Side-effects occurred in 69% of 5-fluorouracil patients and 41% of mitomycin C patients. Five patients (6%) required intervention for treatment-related side-effects in the 5-fluorouracil group versus 11 (17%) in the mitomycin C group. No vision-threatening complications were noted. Conclusions - Long-term recurrence of localised ocular surface squamous neoplasia is rare when topical 5-fluorouracil or mitomycin C are used as adjunctive treatment to surgical excision. While side-effects are common, the majority are transient and rarely limit compliance.
Keywords: Chemotherapy; OSSN; ocular surface tumours; ocular oncology
Description: Article first published online: 13 SEP 2013
Rights: © 2013 Royal Australian and New Zealand College of Ophthalmologists
RMID: 0020138032
DOI: 10.1111/ceo.12184
Appears in Collections:Opthalmology & Visual Sciences publications

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