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Type: Journal article
Title: Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men
Author: Thomas, N.
Morris, H.
Scopacasa, F.
Wishart, J.
Need, A.
Citation: Age and Aging, 1999; 28(2):217-220
Issue Date: 1999
ISSN: 0002-0729
Abstract: BACKGROUND:dehydro-epiandrosterone sulphate (DHEAS) has been reported to ameliorate diabetes mellitus in rats. AIM:we investigated the relationships between plasma glucose, age, serum DHEAS and weight in healthy men. METHODS:we measured the serum DHEAS, fasting plasma glucose, plasma cortisol and body mass index in 169 subjects (mean age 46.5 years). RESULTS:there was a significant decline in serum DHEAS with age (P < 0.0001). Multiple linear regression showed significant relationships with plasma glucose for all measured variables. Age was not a significant determinant of plasma glucose after adjusting for log serum DHEAS, body mass index and log serum cortisol. CONCLUSIONS:a lowered serum DHEAS is paralleled by an elevated plasma glucose within the normal reference interval, and this may contribute to the rise in fasting plasma glucose which occurs with ageing.
Keywords: Humans; Dehydroepiandrosterone Sulfate; Blood Glucose; Body Mass Index; Aging; Adult; Aged; Aged, 80 and over; Middle Aged; Male
RMID: 0030005158
DOI: 10.1093/ageing/28.2.217
Appears in Collections:Medicine publications

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