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|Title:||Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men|
|Citation:||Age and Aging, 1999; 28(2):217-220|
|Publisher:||OXFORD UNIV PRESS|
|Abstract:||BACKGROUND:dehydro-epiandrosterone sulphate (DHEAS) has been reported to ameliorate diabetes mellitus in rats. AIM:we investigated the relationships between plasma glucose, age, serum DHEAS and weight in healthy men. METHODS:we measured the serum DHEAS, fasting plasma glucose, plasma cortisol and body mass index in 169 subjects (mean age 46.5 years). RESULTS:there was a significant decline in serum DHEAS with age (P < 0.0001). Multiple linear regression showed significant relationships with plasma glucose for all measured variables. Age was not a significant determinant of plasma glucose after adjusting for log serum DHEAS, body mass index and log serum cortisol. CONCLUSIONS:a lowered serum DHEAS is paralleled by an elevated plasma glucose within the normal reference interval, and this may contribute to the rise in fasting plasma glucose which occurs with ageing.|
|Keywords:||Humans; Dehydroepiandrosterone Sulfate; Blood Glucose; Body Mass Index; Aging; Adult; Aged; Aged, 80 and over; Middle Aged; Male|
|Appears in Collections:||Medicine publications|
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