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Type: Journal article
Title: Quantitation of Clostridium botulinum organisms and toxin in the feces of an infant with botulism
Author: Paton, J.
Lawrence, A.
Manson, J.
Citation: Journal of Clinical Microbiology, 1982; 15(1):1-4
Publisher: American Society for Microbiology
Issue Date: 1982
ISSN: 0095-1137
Statement of
James C. Paton, Andrew J. Lawrence, and James I. Manson
Abstract: A 4-month-old boy presented with symptoms and signs characteristic of infant botulism. Examination of feces revealed Clostridium botulinum type B and type B toxin. The numbers of C. botulinum and the amount of toxin in feces were measured throughout the 4-week period in hospital. The maximum numbers and amounts were detected in a fecal specimen collected 16 days after admission: this contained 8.4 X 10(6) C. botulinum type B colony-forming units and 61,440 mouse 100% lethal doses of type B toxin per g (wet weight) of feces. This latter figure is the highest fecal toxin titer reported yet for a case of infant botulism. By day 16, however, substantial improvement in the patient's clinical condition had occurred. This suggests that initiation of recovery from infant botulism is not necessarily preceded by a reduction in the numbers of C. botulinum organisms and the quantity of toxin in the gut.
Keywords: Feces
Clostridium botulinum
Botulinum Toxins
Action Potentials
Rights: Copyright status unknown
DOI: 10.1128/jcm.15.1.1-4.1982
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Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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