Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85809
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Type: Journal article
Title: Epicardial adipose tissue and atrial fibrillation
Author: Hatem, S.
Sanders, P.
Citation: Cardiovascular Research, 2014; 102(2):205-213
Publisher: Elsevier Science
Issue Date: 2014
ISSN: 0008-6363
1755-3245
Statement of
Responsibility: 
Stéphane N. Hatem and Prashanthan Sanders
Abstract: Atrial fibrillation (AF) is the most frequent cardiac arrhythmia in clinical practice. AF is often associated with profound functional and structural alterations of the atrial myocardium that compose its substrate. Recently, a relationship between the thickness of epicardial adipose tissue (EAT) and the incidence and severity of AF has been reported. Adipose tissue is a biologically active organ regulating the metabolism of neighbouring organs. It is also a major source of cytokines. In the heart, EAT is contiguous with the myocardium without fascia boundaries resulting in paracrine effects through the release of adipokines. Indeed, Activin A, which is produced in abundance by EAT during heart failure or diabetes, shows a marked fibrotic effect on the atrial myocardium. The infiltration of adipocytes into the atrial myocardium could also disorganize the depolarization wave front favouring micro re-entry circuits and local conduction block. Finally, EAT contains progenitor cells in abundance and therefore could be a source of myofibroblasts producing extracellular matrix. The study on the role played by adipose tissue in the pathogenesis of AF is just starting and is highly likely to uncover new biomarkers and therapeutic targets for AF.
Keywords: Atrial fibrillation; cardiac adipose tissue; cardiac fat depot
Rights: © The Author 2014
RMID: 0020138382
DOI: 10.1093/cvr/cvu045
Appears in Collections:Medicine publications

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