Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/86316
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Type: Journal article
Title: Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women
Author: van der Steeg, J.
Steures, P.
Eijkemans, M.
Habbema, J.
Hompes, P.
Burggraaff, J.
Oosterhuis, G.
Bossuyt, P.
van der Veen, F.
Mol, B.
Citation: Human Reproduction, 2008; 23(2):324-328
Publisher: Oxford University Press
Issue Date: 2008
ISSN: 0268-1161
1460-2350
Statement of
Responsibility: 
Jan Willem van der Steeg, Pieternel Steures, Marinus J.C. Eijkemans, J. Dik F. Habbema, Peter G.A. Hompes, Jan M. Burggraaff, G. Jur E. Oosterhuis, Patrick M.M. Bossuyt, Fulco van der Veen and Ben W.J. Mol
Abstract: BACKGROUND Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m2. Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m2 increase [hazard ratio: 0.96 (95% CI 0.91–0.99)]. CONCLUSIONS These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.
Keywords: Obesity; subfertility; pregnancy chance; spontaneous conception
Description: First published online: December 11, 2007
Rights: © The Author 2007
RMID: 0020136862
DOI: 10.1093/humrep/dem371
Appears in Collections:Obstetrics and Gynaecology publications

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