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Type: Journal article
Title: Serial monoxenous transmission of Toxoplasma gondii in cats
Author: Awobode, H.
Paul, A.
Sengoku-Graham, H.
Clem, R.
Mateus-Pinilla, N.
McAllister, M.
Citation: Journal of Parasitology, 2013; 99(6):1122-1124
Publisher: American Society of Parasitologists
Issue Date: 2013
ISSN: 0022-3395
Statement of
H. O. Awobode, A. J. Paul, H. Sengoku-Graham, R. W. Clem, N. E. Mateus-Pinilla, and M. M. McAllister
Abstract: Oral administration of Toxoplasma gondii oocysts to cats (i.e., monoxenous transmission) typically induces patent infections in fewer than half of test subjects. In the present study, oral administration of T. gondii oocysts to 5 kittens induced a patent infection in 2 of them, but only 1 kitten shed enough oocysts to enable further study. Those monoxenously-produced oocysts were administered to another kitten, which produced a second generation of monoxenous oocysts, and then those were used to induce a third generation of monoxenous oocysts. These results provide a rationale to develop a strain of T. gondii that has efficient direct transmission. The isolate of T. gondii that was able to be passaged in this manner has been designated the Dubey strain and cultured tachyzoites have been donated to a repository.
Keywords: Animals
Mice, Inbred ICR
Toxoplasmosis, Animal
Cat Diseases
Serial Passage
Rights: © American Society of Parasitologists 2013
DOI: 10.1645/13-280.1
Appears in Collections:Animal and Veterinary Sciences publications
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