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Type: Journal article
Title: Sebaceous carcinoma in Japanese patients: clinical presentation, staging and outcomes
Author: Watanabe, A.
Sun, M.
Pirbhai, A.
Ueda, K.
Katori, N.
Selva, D.
Citation: British Journal of Ophthalmology, 2013; 97(11):1459-1463
Publisher: BMJ Publishing Group
Issue Date: 2013
ISSN: 0007-1161
Statement of
Akihide Watanabe, Michelle T Sun, Adnan Pirbhai, Kosuke Ueda, Nobutada Katori, Dinesh Selva
Abstract: AIM: To describe the clinical features, management and correlation of the American Joint Committee on Cancer tumour node metastasis (TNM) staging for eyelid carcinoma with outcomes in Japanese patients with sebaceous carcinoma. METHODS: Multicentre retrospective review of 63 Japanese patients. Tumours were staged using the American Joint Committee on Cancer 7th edition TNM criteria. RESULTS: A distinct mass was the initial presentation in 94% and correct initial diagnosis made in 57% patients. Most tumours (60%) presented at stage T2aN0M0. The remaining TNM stages were: T2bN0M0 (25%); T3aN0M0 (9%); T3bN0M0 (2%); T2bN1M0 (2%); T3bN1M1 (2%). Frozen section controlled excision was performed in 81%. One patient required an orbital exenteration. Median follow-up was 4.2 years. Local recurrence occurred in four patients treated with frozen section controlled excision. Five patients had regional nodal metastases, two of which had T2aN0M0 lesions. T3a tumours and greater were significantly associated with local recurrence but not regional nodal metastasis. One patient died due to disease. One patient is alive with disease, and remaining patients were alive without disease at last follow-up. CONCLUSIONS: In this Japanese cohort, an eyelid mass was the main clinical presentation of sebaceous carcinoma. Contrary to previous reports, T2a tumours smaller than 10 mm were associated with regional nodal metastases.
Keywords: No keywords specified
Description: This article has a correction, please see: Br J Ophthalmol 2014;98:286
Rights: © 2013 by the BMJ Publishing Group Ltd.
RMID: 0030015166
DOI: 10.1136/bjophthalmol-2013-303758
Appears in Collections:Opthalmology & Visual Sciences publications

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