Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNeed, A.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorStiliano, A.en
dc.contributor.authorScopacasa, F.en
dc.contributor.authorMorris, H.en
dc.contributor.authorChatterton, B.en
dc.identifier.citationEuropean Journal of Clinical Investigation, 1996; 26(9):793-796en
dc.description.abstractThree restriction fragment length polymorphisms in the vitamin D receptor gene have been associated with a low bone density in twin and female population studies, but no studies have been conducted exclusively in men. We studied 146 normal men aged 20-83 years. Bone density was measured in the spine, hip, whole body and forearm, and the Bsm polymorphism for the vitamin D receptor was detected by the polymerase chain reaction. Men with genotype BB tended to have a lower bone density at all but one site than the other genotypes. In the men < or = 50 years of age bone density in the forearm was 7% lower in the BB than the Bb and bb groups (P = 0.030) but bone mineral content did not differ between the groups. Bone area was greater in the BB genotype at all sites. This was statistically significant in the forearm (P = 0.026). We conclude that BB genotype is associated with lower bone density in men, which may be due to larger bone size rather than reduced bone mass.en
dc.subjectHumans; Receptors, Calcitriol; Absorptiometry, Photon; Body Constitution; Bone Development; Bone Density; Genotype; Polymorphism, Restriction Fragment Length; Adult; Aged; Aged, 80 and over; Middle Aged; Maleen
dc.titleVitamin D receptor genotypes are related to bone size and bone density in men.en
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.