Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8798
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dc.contributor.authorNeed, A.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorStiliano, A.en
dc.contributor.authorScopacasa, F.en
dc.contributor.authorMorris, H.en
dc.contributor.authorChatterton, B.en
dc.date.issued1996en
dc.identifier.citationEuropean Journal of Clinical Investigation, 1996; 26(9):793-796en
dc.identifier.issn0014-2972en
dc.identifier.issn1365-2362en
dc.identifier.urihttp://hdl.handle.net/2440/8798-
dc.description.abstractThree restriction fragment length polymorphisms in the vitamin D receptor gene have been associated with a low bone density in twin and female population studies, but no studies have been conducted exclusively in men. We studied 146 normal men aged 20-83 years. Bone density was measured in the spine, hip, whole body and forearm, and the Bsm polymorphism for the vitamin D receptor was detected by the polymerase chain reaction. Men with genotype BB tended to have a lower bone density at all but one site than the other genotypes. In the men < or = 50 years of age bone density in the forearm was 7% lower in the BB than the Bb and bb groups (P = 0.030) but bone mineral content did not differ between the groups. Bone area was greater in the BB genotype at all sites. This was statistically significant in the forearm (P = 0.026). We conclude that BB genotype is associated with lower bone density in men, which may be due to larger bone size rather than reduced bone mass.en
dc.language.isoenen
dc.publisherBLACKWELL SCIENCE LTDen
dc.subjectHumans; Receptors, Calcitriol; Absorptiometry, Photon; Body Constitution; Bone Development; Bone Density; Genotype; Polymorphism, Restriction Fragment Length; Adult; Aged; Aged, 80 and over; Middle Aged; Maleen
dc.titleVitamin D receptor genotypes are related to bone size and bone density in men.en
dc.typeJournal articleen
dc.identifier.rmid0030004983en
dc.identifier.doi10.1046/j.1365-2362.1996.2080554.xen
dc.identifier.pubid68989-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]en
Appears in Collections:Medicine publications

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