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https://hdl.handle.net/2440/8880
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Type: | Journal article |
Title: | PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in supression of hematopoiesis |
Author: | Levesque, J.P. Zannettino, A. Pudney, M. Niutta, S. Haylock, D. Snapp, K. Kansas, G. Berndt, M. Simmons, P. |
Citation: | Immunity, 1999; 11(3):369-378 |
Publisher: | CELL PRESS |
Issue Date: | 1999 |
ISSN: | 1074-7613 1097-4180 |
Statement of Responsibility: | Jean-Pierre Lévesque, Andrew C.W Zannettino, Melanie Pudney, Silvana Niutta, David N Haylock, Karen R Snapp, Geoffrey S Kansas, Michael C Berndt, Paul J Simmons |
Abstract: | Cellular interactions are critical for the regulation of hematopoiesis. The sialomucin PSGL-1/CD162 mediates the attachment of mature leukocytes to P-selectin. We now show that PSGL-1 also functions as the sole receptor for P-selectin on primitive human CD34+ hematopoietic progenitor cells (HPC). More importantly, ligation of PSGL-1 by immobilized or soluble ligand or anti-PSGL-1 antibody results in a profound suppression of HPC proliferation stimulated by potent combinations of early acting hematopoietic growth factors. These data demonstrate an unanticipated but extremely marked growth-inhibitory effect of P-selectin on hematopoiesis and provide direct evidence that PSGL-1, in addition to its well-documented role as an adhesion molecule on mature leukocytes, is a potent negative regulator of human hematopoietic progenitors. |
Keywords: | Bone Marrow Cells Hematopoietic Stem Cells Cells, Cultured CHO Cells Animals Humans NAD+ Nucleosidase ADP-ribosyl Cyclase Granulocyte Colony-Stimulating Factor Interleukin-3 Membrane Glycoproteins P-Selectin Antigens, Differentiation Antigens, CD Antigens, CD34 Stem Cell Factor Interleukin-6 Ligands Cell Adhesion Cell Division Apoptosis Hematopoiesis Solubility Cricetinae ADP-ribosyl Cyclase 1 |
DOI: | 10.1016/S1074-7613(00)80112-0 |
Published version: | http://dx.doi.org/10.1016/s1074-7613(00)80112-0 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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