Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8930
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Type: Journal article
Title: Discordance between bone turnover and bone loss: effects of aging and ovariectomy in the rat
Author: Baldock, P.
Need, A.
Moore, R.
Durbridge, T.
Morris, H.
Citation: Journal of Bone and Mineral Research, 1999; 14(8):1442-1448
Publisher: AMER SOC BONE & MINERAL RES
Issue Date: 1999
ISSN: 0884-0431
1523-4681
Statement of
Responsibility: 
Paul A. J. Baldock, Allan G. Need, Robert J. Moore, Timothy C. Durbridge,. Howard A. Morris
Abstract: Mechanical strain maintains bone architecture even under conditions of increased bone turnover such as occurs with ovarian hormone deficiency. The rat distal femur contains two sites that apparently experience different levels of mechanical strain and therefore the rat is a suitable model for investigating such effects. The femoral epiphysis experiences higher strain energy compared with the metaphysis and we report the effects of aging between 7 and 12 months and the postovariectomy effects over the same time period on cancellous bone variables measured at these two sites. Age-related bone loss in sham-operated (Sham) animals occurred in both regions, with a greater fall in the metaphysis than in the epiphysis (trabecular bone volume [BV/TV, %] Mean [SEM] Metaphysis: day 0, 25.9 [2.4]; day 150, 8.8 [1.3]: Epiphysis: day 0, 44.8 [1.7]; day 150, 36.7 [1.4] [p < 0.0001]). With ovariectomy (OVX) there was a 73% reduction in cancellous bone at the metaphysis compared with no specific loss at the epiphysis (BV/TV [%] OVX: Metaphysis: day 150, 2.4 [0.4] [p < 0.01 compared with Sham]: Epiphysis: day 150 29.3 [2.7] [NS]). Osteoblast cell activity and osteoclast surface were increased after ovariectomy in both regions. The mineral apposition rate decreased at 9.5 months of age in both regions (p < 0.0001), independent of ovariectomy, and was coincident with a reduction in trabecular number in the epiphyses of both operative groups and in the metaphysis of the ovary-intact group. These data suggest that local mechanical strain governs bone balance with aging and that architectural changes resulting from age-related bone loss may mirror those following estrogen deficiency but occur via a different cellular mechanism.
Keywords: Epiphyses; Femur; Ovary; Animals; Rats; Rats, Sprague-Dawley; Bone Resorption; Ovariectomy; Aging; Bone Development; Biomechanics; Female
Rights: Copyright © 1999 American Society for Bone and Mineral Research
RMID: 0030004901
DOI: 10.1359/jbmr.1999.14.8.1442
Appears in Collections:Medicine publications

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