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https://hdl.handle.net/2440/89974
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Type: | Journal article |
Title: | Association of moderate to severe lower urinary tract symptoms with incident type 2 diabetes and heart disease |
Author: | Kupelian, V. Araujo, A. Wittert, G. McKinlay, J. |
Citation: | The Journal of Urology, 2015; 193(2):581-586 |
Publisher: | Elsevier |
Issue Date: | 2015 |
ISSN: | 0022-5347 1527-3792 |
Statement of Responsibility: | Varant Kupelian, Andre B. Araujo, Gary A. Wittert, John B. McKinlay |
Abstract: | PURPOSE: Increasing evidence suggests a possible link between lower urinary tract symptoms and chronic illnesses. We determined whether lower urinary tract symptoms are associated with incident type 2 diabetes and heart disease in a population based study. MATERIALS AND METHODS: BACH is a population based epidemiological survey of urological symptoms. A multistage, stratified, cluster sample design was used to obtain a random sample of 4,144 men and women 30 to 79 years old at baseline. Median followup was 4.8 years between baseline (2002 to 2005) and followup (2006 to 2010). Type 2 diabetes and heart disease were assessed by self-report. Lower urinary tract symptoms were assessed by the AUA-SI, and voiding and storage subscores. Logistic regression was used to estimate the OR and 95% CI, and adjust for potential confounders. RESULTS: In participants with a body mass index of 30 kg/m(2) or greater the adjusted ORs for incident heart disease were 1.89 (95% CI 1.05, 3.39) for AUA-SI 8 or greater and 2.32 (95% CI 1.33, 4.05) for a storage score of 4 or greater. In participants with abdominal obesity the adjusted ORs for incident type 2 diabetes were 2.06 (95% CI 1.19, 3.55) for AUA-SI 8 or greater and 1.81 (95% CI 1.04, 3.15) for a storage score of 4 or greater. Lower urinary tract symptoms (AUA-SI 8 or greater) were also predictive of type 2 diabetes in men and women younger than 50 years (adjusted OR 2.37, 95% CI 1.18, 4.80). CONCLUSIONS: Longitudinal results of BACH suggest that lower urinary tract symptoms are a marker of increased risk for type 2 diabetes and heart disease in obese men and women. The increased risk in younger men and women suggests that lower urinary tract symptoms may be an indicator of impending disease. |
Keywords: | diabetes mellitus heart diseases lower urinary tract symptoms risk type 2 urinary tract |
Rights: | Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.juro.2014.08.097 |
Published version: | http://dx.doi.org/10.1016/j.juro.2014.08.097 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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