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Type: Journal article
Title: Understanding the pharmacology of headache
Author: Rolan, P.
Citation: Current Opinion in Pharmacology, 2014; 14(1):30-33
Publisher: Elsevier
Issue Date: 2014
ISSN: 1471-4892
Statement of
Paul Edward Rolan
Abstract: Migraine continues to be the most common of the debilitating headaches. Existing acute headache treatments are not always satisfactory, and current research is focussed on targeting neuroinflammatory pathways with drugs that are devoid of vascular action. Current prophylactic drugs are largely centred around antihypertensive, anticonvulsant and antidepressant drugs, although not all drugs of all sub-classes in these categories are effective. Selective agents which target the neuroinflammatory process including targets such as calcitonin gene related peptide, and PANNEXIN 1 may have clinical utility.
Keywords: Animals; Humans; Headache; Calcitonin Gene-Related Peptide; Anticonvulsants; Antidepressive Agents; Antihypertensive Agents; Drug Design; Migraine Disorders; Molecular Targeted Therapy
Rights: Copyright © 2013
RMID: 0020133552
DOI: 10.1016/j.coph.2013.10.005
Appears in Collections:Pharmacology publications

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