Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/90145
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Type: | Journal article |
Title: | The role of substance P in ischaemic brain injury |
Author: | Turner, R. Vink, R. |
Citation: | Brain Sciences, 2013; 3(1):123-142 |
Publisher: | MDPI |
Issue Date: | 2013 |
ISSN: | 2076-3425 2076-3425 |
Statement of Responsibility: | Renée J. Turner and Robert Vink |
Abstract: | Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and tissue injury following stroke occurs through a number of diverse secondary injury pathways, whose delayed nature provides an opportunity for pharmacological intervention. Amongst these secondary injury factors, increased blood-brain barrier permeability and cerebral oedema are well-documented complications of cerebral ischaemia, whose severity has been shown to be associated with final outcome. Whilst the mechanisms of increased blood-brain barrier permeability and cerebral oedema are largely unknown, recent evidence suggests that the neuropeptide substance P (SP) plays a central role. The aim of this review is to examine the role of SP in ischaemic stroke and report on the potential utility of NK1 tachykinin receptor antagonists as therapeutic agents. |
Keywords: | substance P; neuropeptides; neurogenic inflammation; cerebral oedema; stroke; tachykinin; blood-brain barrier; cerebral ischaemia |
Rights: | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
DOI: | 10.3390/brainsci3010123 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/519365 |
Published version: | http://dx.doi.org/10.3390/brainsci3010123 |
Appears in Collections: | Aurora harvest 2 Medical Sciences publications |
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hdl_90145.pdf | Published version | 1.66 MB | Adobe PDF | View/Open |
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