Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/90218
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Type: Journal article
Title: Selective complex fractionated atrial electrograms targeting for atrial fibrillation study (SELECT AF): a multicenter, randomized trial
Author: Verma, A.
Sanders, P.
Champagne, J.
Macle, L.
Nair, G.
Calkins, H.
Wilber, D.
Citation: Circulation: Arrhythmia and Electrophysiology, 2014; 7(1):55-62
Publisher: Lippincott Williams and Wilkins
Issue Date: 2014
ISSN: 1941-3149
1941-3084
Statement of
Responsibility: 
Atul Verma, Prashanthan Sanders, Jean Champagne, Laurent Macle, Girish M. Nair, Hugh Calkins, David J. Wilber
Abstract: BACKGROUND: This study compared generalized complex fractionated atrial electrograms (CFAE) ablation versus a selective CFAE ablation strategy targeting areas of continuous electric activity. METHODS AND RESULTS: Subjects with symptomatic, persistent/high-burden paroxysmal atrial fibrillation (AF) were enrolled at 6 centers (n=86) and randomized to 1 of 2 arms. For group I, all CFAE regions with an interval confidence level >7 were ablated followed by pulmonary vein isolation (PVI). For group II, only CFAE sites with continuous electric activity were ablated followed by PVI. For PVI, all 4 PV antra were isolated with confirmed entrance block. Subjects were followed for 1 year with a visit, ECG, and 48-hour Holter every 3 months. Symptoms were confirmed by loop recording. The primary end point was freedom from arrhythmia >30 seconds at 1 year. For both group I and II, CFAE ablation prolonged AF cycle length (25±33 versus 23±33 ms; P=0.78) and resulted in similar rates of AF termination (37% versus 28%; P=0.42). Radiofrequency duration during CFAE ablation was significantly less in group II (23±20 versus 38±20 minutes; P=0.002). At 1-year follow-up, freedom from AF/atrial flutter/atrial tachycardia recurrence was significantly higher in group I versus group II after 1 procedure (50% versus 28%; P=0.03). There were also significantly fewer repeat procedures in group I (13% versus 36%; P=0.021). CONCLUSIONS: Continuous electric activity ablation+PVI result in a similar incidence of acute AF termination with significantly less radiofrequency time. However, incidence of repeat procedures and long-term recurrence of AF/atrial flutter/atrial tachycardia are significantly lower using generalized CFAE ablation+PVI. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00926783.
Keywords: Ablation; atrial fibrillation; fractionated electrograms; randomized trial
Rights: © 2014 American Heart Association, Inc
RMID: 0030011225
DOI: 10.1161/CIRCEP.113.000890
Appears in Collections:Medicine publications

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